Wild Lettuce's soothing properties have also been applied to promote sleep, to ease nervous indigestion and other nervous conditions. Wild Lettuce also relieves spasms, and earlier herbal manuals suggest a syrup preparation for allaying coughs.
The effects of ingesting L. virosa are similar to opium, although no opiates are present in the plant. A latex however exists as an extract of the stem secretion of Lactuca virosa, a simple preparation in a manner resembling opium, which is called lactucarium. Effects are felt quickly but do not last long, between half an hour to a couple of hours. They dwindle slowly. The plant has been used as an anesthetic and a Sleep aid.
Many add the greens to salads, though the leaves of L. virosa are more bitter than other salad greens.
It is said to be also a mild diaphoretic and diuretic, easing colic, inducing sleep and allaying cough.